E3泛素连接酶通过特异性识别底物调控蛋白质泛素化修饰，在细胞周期、免疫应答、代谢调控及神经退行性疾病中发挥核心作用。本文系统解析了HECT、RING、U-box及RBR型E3 ligases的结构与功能，阐明其在癌症（如通过MDM2降解p53）、心血管疾病（如WWP2介导的心肌纤维 ...

Transverse tubules (T-tubules) play a significant role in muscle contraction. However, the underlying mechanism of their ...

本综述系统阐述了RING-UIM E3连接酶（RING-UIM E3 ligases）亚家族（包括RNF114、RNF125、RNF138和RNF166）在癌症发生发展中的“双刃剑 ...

In eukaryotes, ubiquitination is an important posttranslational process achieved through a cascade of ubiquitin-activating (E1), conjugating (E2), and ligase (E3) enzymes. Many pathogenic bacteria ...

Ethylene influences plant growth, development, and stress responses via crosstalk with other phytohormones; however, the underlying molecular mechanisms are still unclear. Here, we describe a ...

Targeted protein degradation (TPD) has transformed cancer drug discovery by enabling removal of harmful proteins using small molecule degraders. PROTACs (Proteolysis Targeting Chimeras) and MGDs ...