Pragmatic clinical trials are designed to evaluate the effectiveness of interventions under the conditions of routine clinical practice, thereby addressing the gap between traditional randomised ...

A new thought piece led by the Harvard Pilgrim Health Care Institute with collaborators from Duke University and Kaiser Permanente Washington Health Research Institute highlights the challenges facing ...

Introduction Each year, millions of people experience recurrent diverticulitis episodes. Elective sigmoid colon resection reduces the risk of recurrence, but The American Society of Colon and Rectal ...

Findings from the first-ever prospective trial including a randomized pathway comparing surgery to non-surgical treatment of malignant bowel obstruction (MBO) provide important evidence to help inform ...

PHILADELPHIA, Aug. 19, 2025 /PRNewswire/ -- TransCelerate BioPharma (TransCelerate), a nonprofit organization dedicated to improving the health of people around the world by accelerating and ...

Double-blind randomized clinical trials (RCTs) are the gold standard for evaluating how effective a treatment is as an intervention in a clinical setting. When it comes to understanding how a ...

That a new cancer trial is about to start in the US is positive but not out of the ordinary, right? Except it is. This trial will be one of the first undertaken in a real-world clinical setting and ...

The authors examine the origin, benefits, and challenges of pragmatic clinical trials to assess the ultimate value of this research design. Pragmatic clinical trials (PCTs), which test if and how ...

Pragmatic trials may offer one way to increase minority populations in multiple sclerosis (MS) studies, investigators for the DELIVER-MS trial suggested. Race and ethnicity did not appear to influence ...