Genetic circuit engineering is the synthesis of unnatural DNA segments encoding protein or RNA molecules that control each other’s levels. Genetic circuit engineering is the bottom-up, local approach ...

How high-fat diet disrupts brain circuits that regulate food intake is unclear. Here, the authors show such a diet downregulates Hcn1 and Gad2 in lateral septum, which in turn disrupts circuit ...

This important study combines optogenetic manipulations and wide-field imaging to show that the retrosplenial cortex controls behavioral responses to whisker deflection in a context-dependent manner.