Purpose: To develop a high resolution microarray based method to detect single- and multiexons gene deletions and duplications. Methods: We have developed a high-resolution comparative genomic ...

Comparative genomic hybridization (CGH) is a technique that has greatly facilitated detection of gains and losses in DNA copy number, and has been of particular utility in elucidating the pattern of ...

为探究儿童急性淋巴细胞白血病（ALL）的发病机制，研究人员对 67 例马来西亚正常核型的儿童 ALL 患者开展基于阵列比较基因组杂交（array-CGH）研究。结果发现了致病性拷贝数变异（CNVs）和意义不明变异（VUS），这有助于白血病分类和个性化治疗123。 儿童急性 ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

Early efforts to examine genomic changes in the clinical setting relied on cytogenetic techniques such as chromosome karyotyping, a widely used approach to examine chromosomes and identify changes ...