The complement system in teleost fish constitutes a cornerstone of innate defence, integrating classical, lectin and alternative activation routes to eliminate pathogens and shape inflammatory ...

Innate immunity constitutes the body’s first line of defence against infection and tissue disruption. It relies on physical barriers such as skin and mucosa, cellular sentinels including neutrophils, ...

Innate lymphoid cells, which curiously behave like T cells even though they don’t recognize specific antigens, show promise as a potential cancer therapeutic. In the years that followed, other groups ...

Dozens of new discoveries reveal that defenses evolved by bacteria and viruses billions of years ago still define our own innate immune system. Evolutionary arms races — where one species is pitted ...

Researchers have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against potential ...

Complement 3 glomerulopathy (C3G) is a rare kidney disease that affects your body’s innate immune system (complement system). Complement 3 glomerulopathy (C3G) is a kidney disease that’s caused by ...

Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. Clinical ...

Scientists generally agree that eukaryotes, the domain of life whose cells contain nuclei and that includes almost all multicellular organisms, originated from a process involving the symbiotic union ...

Unlike transient innate immune activation, trained immunity is characterized by long-lasting but reversible functional reprogramming of monocytes, macrophages, natural killer (NK) cells, and ...

1 Department of Internal Medicine, Division of Rheumatology, University of New Mexico, Albuquerque, NM 2 Biomedical Research Institute of New Mexico, Albuquerque, NM 3 Department of Molecular Genetics ...