CGSchNet, a fast machine-learned model, simulates proteins with high accuracy, enabling drug discovery and protein engineering for cancer treatment. Operating significantly faster than traditional all ...

The MIDAS platform enables rapid engineering and testing of thousands of protein variants simultaneously. The platform could ...

In a new study published in Nature titled, “Custom CRISPR-Cas9 PAM variants via scalable engineering and machine learning,” researchers from Massachusetts General Hospital (MGH) and Harvard Medical ...

Their overview highlights innovative methods based on B-factor analysis, ancestral sequence reconstruction (ASR), and machine learning (ML), providing tools to design enzymes that withstand high ...

Northwestern Medicine scientists have developed a new experimental method to analyze conformational fluctuations in protein ...

It has long been thought that protein function and stability are highly sensitive to changes in the composition of the internal structures, or protein cores. However, a large-scale experiment probing ...