St. Jude Children's Research Hospital scientists have identified specific DNA variants in the non-coding regions of the genome contributing to chemotherapy resistance in acute lymphoblastic leukemia ...

Noncoding elements in the genome, such as enhancers, silencers, and insulators, play important roles in gene expression and thus cellular behavior. Therefore, these elements may be of particular ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...

The accumulation of mutations in DNA is often mentioned as an explanation for the aging process, but it remains just one hypothesis among many. A team from the University of Geneva (UNIGE), in ...

Researchers from Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania (Penn Medicine) have successfully employed an algorithm to identify ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

Using artificial intelligence, Garvan Institute researchers have found potential cancer drivers hidden in so-called 'junk' regions of DNA, opening up possibilities for a new approach to diagnosis and ...

The human genome contains about 20,000 protein-coding genes, but that only accounts for roughly two percent of the genome. For many years, it was easier for scientists to simply ignore all of that ...

Scientists have found new genetic causes for diabetes in babies – in a part of the genome that has historically been overlooked in genetic studies. Until recently, most research has investigated ...

When AlphaFold solved the protein-folding problem in 2020, it showed that artificial intelligence could crack one of biology’s deepest mysteries: how a string of amino acids folds itself into a ...