A wave of spatial transcriptomics studies has produced gene-expression atlases that span entire organs and whole organisms, ...

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Transcriptomics is the study of the transcriptome, which is the complete set of RNA transcripts produced by the genome at a specific time or under particular conditions. It involves the analysis of ...

Applying single-cell RNA sequencing has led researchers to be able to profile the entire transcriptome of cells. However, these transcriptomes prove difficult to link back to their original location ...

Scientists at James Cook University have uncovered new insights into how the body contains latent tuberculosis, using a ...

Nova-ST, a new spatial transcriptomics technique, has been introduced by researchers based at Vlaams Instituut voor Biotechnologie (VIB), Katholieke Universiteit (KU) Leuven. According to the ...

Researchers at the Max Delbrück Center have developed an open-source spatial transcriptomics (ST) platform, called Open-ST, that creates 3D molecular maps from patient tissue samples with subcellular ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

Researchers reveal the intricate molecular landscape of triple-negative breast cancer (TNBC), uncovering actionable spatial archetypes and gene signatures that pave the way for personalized therapies ...