Wnt signalling encompasses a network of secreted glycoproteins and their receptors, which orchestrate fundamental processes in the nervous system from embryonic patterning to synaptic plasticity in ...

The canonical Wnt signaling pathway. The left panel (A) demonstrates the activated Wnt signaling cascade, while the right side portrays the inhibited Wnt signaling cascade. Wnt binds to the Fz ...

The noncanonical Wnt/PCP pathway. The binding of Wnt ligands leads to the phosphorylation of Dvl, which recruits Invs, Par6, and Smurf. Smurf ubiquitinates the inhibitory protein Prickle, targeting it ...

Researchers from Tel Aviv Sourasky Medical Center presented data from a study that aimed to investigate the genetic mechanisms underlying yellow nail syndrome (YNS), a rare disorder characterized by ...

Hepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates. It arises from chronic liver diseases, including hepatitis B or C infections, ...

A new study reveals why some pancreatic and colorectal tumors resist targeted anti-Wnt drugs and suggests how to overcome it, offering new hope to patients with fully treatment-resistant cancers.