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🐭 ️Hb "Copy-pasting" CDRs onto a human framework often kills affinity. Why? Antibody humanization requires more than just swapping sequences. The structural support of the binding loop is key. 📐 Structural Insights: • 🏗️ The role of framework residues (Vernier zone) in loop support. • 📉 Why affinity drops after simple ...
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